Hidenori Wake Selected Research

histidine-rich proteins

1/2021	Histidine-rich glycoprotein as a prognostic biomarker for sepsis.
12/2020	An Evaluation of the Activity of Histidine-Rich Glycoprotein on Differentiated Neutrophil-Like Cells from Human Cell Lines.
9/2020	Histidine-rich glycoprotein possesses antioxidant activity through self-oxidation and inhibition of hydroxyl radical production via chelating divalent metal ions in Fenton's reaction.
6/2020	Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A.
1/2020	[Various functions of plasma histidine-rich glycoprotein and its clinical application as the biomarker and therapeutic drug for sepsis].
10/2019	Histidine-rich Glycoprotein Modulates the Blood-vascular System in Septic Condition.
1/2019	Histidine-rich glycoprotein augments natural killer cell function by modulating PD-1 expression via CLEC-1B.
1/2019	Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-κB and MAPK signal pathway.
10/2018	Histidine-Rich Glycoprotein Suppresses Hyperinflammatory Responses of Lung in a Severe Acute Pancreatitis Mouse Model.
3/2018	Effects of Histidine-rich glycoprotein on erythrocyte aggregation and hemolysis: Implications for a role under septic conditions.

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Hidenori Wake Research Topics

Disease

13	Sepsis (Septicemia) 04/2022 - 07/2016
12	Inflammation (Inflammations) 01/2022 - 09/2009
6	Neuralgia (Stump Neuralgia) 01/2022 - 01/2019
5	Pain (Aches) 01/2022 - 01/2019
5	Brain Injuries (Brain Injury) 12/2020 - 09/2012
5	Brain Edema (Cerebral Edema) 02/2019 - 05/2011
4	Diabetes Complications 01/2021 - 03/2010
3	Hypersensitivity (Allergy) 01/2022 - 01/2019
3	Infections 01/2021 - 01/2018
3	Ischemia 12/2020 - 12/2007
3	Thromboinflammation 09/2020 - 07/2016
3	Hyperalgesia 06/2020 - 10/2018
3	Traumatic Brain Injuries (Traumatic Brain Injury) 02/2019 - 09/2012
3	Neoplasms (Cancer) 01/2019 - 11/2009
3	Pneumonia (Pneumonitis) 10/2018 - 04/2016
2	Neuroinflammatory Diseases 01/2022 - 01/2020
2	Cognitive Dysfunction 01/2022 - 02/2019
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2021 - 01/2018
2	Bacterial Infections (Bacterial Infection) 01/2021 - 01/2018
2	Wounds and Injuries (Trauma) 12/2020 - 04/2019
2	Hemorrhage 12/2020 - 10/2017
2	Disseminated Intravascular Coagulation 01/2020 - 10/2019
2	Multiple Organ Failure (MODS) 01/2020 - 10/2019
2	Periodontitis 01/2020 - 01/2018
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2020 - 05/2011
2	Peripheral Nervous System Diseases (PNS Diseases) 10/2019 - 10/2018
2	Edema (Dropsy) 10/2018 - 04/2016
2	Brain Infarction 05/2011 - 12/2007
1	Diabetic Angiopathies (Diabetic Angiopathy) 11/2021
1	Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar) 07/2021
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 07/2021
1	Chronic Pain 04/2021
1	Trigeminal Nerve Diseases (Trigeminal Nerve Disorders) 04/2021
1	Trigeminal Nerve Injuries 04/2021
1	Encephalitis (Encephalitis, Rasmussen) 12/2020
1	Central Nervous System Diseases (CNS Diseases) 12/2020
1	Epilepsy (Aura) 12/2020
1	Myeloid Leukemia (Leukemia, Myelocytic) 12/2020

Drug/Important Bio-Agent (IBA)

30	HMGB1 Protein (HMG1)IBA 04/2022 - 12/2007
14	histidine-rich proteinsIBA 01/2021 - 11/2009
7	Advanced Glycation End ProductsIBA 11/2021 - 03/2010
7	Monoclonal AntibodiesIBA 04/2021 - 12/2007
5	glycolaldehydeIBA 11/2021 - 09/2009
5	Proteins (Proteins, Gene)FDA Link 12/2020 - 01/2018
4	LipopolysaccharidesIBA 04/2022 - 03/2007
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2018
4	CytokinesIBA 09/2020 - 01/2018
4	GlyceraldehydeIBA 01/2020 - 09/2009
3	Minocycline (Cyclops)FDA LinkGeneric 01/2022 - 10/2018
3	Glycoproteins (Glycoprotein)IBA 01/2021 - 10/2019
3	Neutralizing AntibodiesIBA 12/2020 - 01/2018
3	Pharmaceutical PreparationsIBA 12/2020 - 11/2009
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2020 - 01/2018
3	ThrombomodulinIBA 06/2020 - 10/2018
2	Glycyrrhizic Acid (Glycyrrhizin)IBA 01/2022 - 10/2014
2	Clodronic Acid (Clodronate)IBA 01/2022 - 10/2018
2	Glutamic Acid (Glutamate)FDA Link 01/2021 - 01/2019
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 01/2019
2	Receptor for Advanced Glycation End ProductsIBA 12/2020 - 04/2016
2	Therapeutic UsesIBA 06/2020 - 01/2017
2	Nuclear Proteins (Protein, Nuclear)IBA 06/2020 - 01/2019
2	Acetylcysteine (Siran)FDA LinkGeneric 01/2020 - 10/2018
2	InterleukinsIBA 01/2020 - 01/2018
2	LigandsIBA 01/2020 - 01/2018
2	Interleukin-6 (Interleukin 6)IBA 01/2020 - 01/2017
2	Paclitaxel (Taxol)FDA LinkGeneric 10/2019 - 10/2018
2	Heparin (Liquaemin)FDA LinkGeneric 10/2019 - 11/2009
2	Heme (Haem)IBA 10/2019 - 03/2018
2	Blood Proteins (Serum Proteins)IBA 01/2018 - 07/2016
1	ribosomal protein L9IBA 04/2022
1	Ribosomal Proteins (Ribosomal Protein)IBA 04/2022
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2022
1	AcidsIBA 01/2022
1	CalciumIBA 01/2022
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2022
1	Liposomes (Liposome)IBA 01/2022
1	Bleomycin (Blenoxane)FDA LinkGeneric 07/2021
1	Small Interfering RNA (siRNA)IBA 07/2021
1	OsteopontinIBA 07/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 07/2021
1	mirogabalinIBA 04/2021
1	AlarminsIBA 04/2021
1	AcetoneIBA 04/2021
1	Macrophage Colony-Stimulating FactorIBA 01/2021
1	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	LipidsIBA 01/2021
1	EndotoxinsIBA 01/2021
1	Nucleic AcidsIBA 01/2021
1	N-Methylaspartate (NMDA)IBA 01/2021
1	Ubiquitin-Specific ProteasesIBA 12/2020
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 12/2020
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2020

Therapy/Procedure

8	Ligation 01/2022 - 03/2010
7	Therapeutics 12/2020 - 05/2011
2	Intraperitoneal Injections 01/2021 - 10/2018
2	Tooth Extraction (Tooth Extractions) 01/2020 - 01/2018
2	Drug Therapy (Chemotherapy) 10/2019 - 10/2018
2	Intravenous Injections 05/2011 - 12/2007
1	Injections 01/2022